The paper looks at marginalization and depopulation of small towns in inland areas by envisaging a possible new Mediterranean spirit in architecture, conceiving the Apennines as a geographical line connecting the Mediterranean to Europe. According to Raffaele Nigro’s thesis, they are a line that establishes links between points, rather than oppositions. A Mediterranean consciousness, which recalls Braudel and Matvejevic, but is also aware of contemporary plagues, from climate change to migration and poly-crisis, and open to a profound knowledge of geographies and contexts, in which architecture and design help to rediscover the dimension of the livability of places, possibly breaking down the perimeters of borders. Grasping this need, the ARÌNT Master’s course has oriented its training in the direction of qualifying a professional figure capable of coordinating regeneration processes, also experimenting with on-field experiences. The course explores regeneration methods starting from certain fixed points: a transdisciplinary outlook, a trans-scalar approach to the study of contexts, weaving of territorial ties, re-appropriation of community spaces in order to build communities, re-use of disused buildings and spaces (contemplating transitory uses), and the triggering of processes.